Over the past three decades, human pancreatic islet isolation and transplantation techniques have developed as a routine clinical procedure for selected patients with type 1 diabetes mellitus.However, due to the donor shortage and required chronic systemic immunosuppression, the widespread application of islet transplantation is limited.To overcome
Effects of copper exposure and recovery in juvenile yellowtail kingfish (Seriola lalandi): Histological, physiological and molecular responses
This study investigated the physiological responses to copper toxicity in liver and gill of juvenile yellowtail kingfish by exposing to 0 (control), 0.0672, 0.12, 0.214, 0.384, 0.672, 1.20, or 2.14 mg/L copper sulfate for 7 days and then recovered for 14 days.The histopathology, enzyme activities and differential gene expression were detected.The r
Unilateral sequential papillophlebitis and central retinal artery occlusion in a young healthy patient
A 23-year-old girl presented to the clinic with metamorphopsia and photopsia in her left eye.After detailed ophthalmic examination, central retinal vein occlusion with 2 SCALP AND HAIR TREATMENT optic disc edema was detected in that eye.Three days after diagnosis, the patient returned to our clinic with visual acuity decrease.Central retinal Protec
Quantitative Prediction of Human Pharmacokinetics and Pharmacodynamics of CKD519, a Potent Inhibitor of Cholesteryl Ester Transfer Protein (CETP)
CKD519, a selective inhibitor of Masalas cholesteryl ester transfer protein(CETP), is undergoing development as an oral agent for the treatment of primary hypercholesterolemia and mixed hyperlipidemia.The aim of this study was to predict the appropriate efficacious dose of CKD519 for humans in terms of the inhibition of CETP activity by developing